DiscoverySeries ·Historical Discoveries in Proteomics

How do we determine the sequence of a protein?

Daniel Martins de Souza

November 4, 2026

1/8

Today we’re launching “Historical Discoveries in Proteomics.” The idea is to share a little bit of information each week about how we’ve progressed from the discovery of proteins to 21st-century proteomics.

Frederick Sanger and Insulin

View post on Instagram

Topics#Proteína#Insulina#Proteomics

More from this series

Historical Discoveries in Proteomics →

Discovery

Relative quantification of the proteome

In the early 21st century, LCMS very quickly established itself as a powerful tool for proteome characterization, necessitating the development of quantitative methods to complement it. Here are a few examples and how they evolved over the course of the first decade of the 2000s.

Nov 4, 2026

Discovery

From 2D Gels to SHOTGUN PROTEOMICS

In this fifth episode, we reach the point where LC-MS/MS takes center stage in proteomics.

Nov 4, 2026

Discovery

2D-PAGE

The first decade of proteomics was centered on two-dimensional electrophoresis. 2D-PAGE, the topic we cover in this fourth historical episode, is one of the cornerstones of proteomics.

Nov 4, 2026