DiscoverySeries ·Historical Discoveries in Proteomics

From 2D Gels to SHOTGUN PROTEOMICS

Daniel Martins de Souza

November 4, 2026

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In this fifth episode, we reach the point where LC-MS/MS takes center stage in proteomics.

Two Eras of Proteomics

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Topics#Shotgun-Proteomics#Proteoma#Proteomics

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In the early 21st century, LCMS very quickly established itself as a powerful tool for proteome characterization, necessitating the development of quantitative methods to complement it. Here are a few examples and how they evolved over the course of the first decade of the 2000s.

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Where did the concept of “proteome” come from?

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